الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Schistosomiasis is one of the 10 tropical diseases especially targeted for control by the Special Program for Research and Training in Tropical Despite major advances in control and substantial decreases in morbidity and mortality. This type of epidemic infection continues to spread to new geographic areas. It has been reported that changes in some enzymes occur during Schistosoma mansoni infection and these enzymes belong to different classes of classifications.
The objective of the present study is to continue the investigation of an enzyme marker for the infection by Schistosoma mansoni. Therefore, it has been performed on some hepatic aminotransferases especially TAT during the infection of mice with Schistosoma mansoni. It has been undertaken to study the characterization of this enzyme from Schistosoma – infected mice compared to control as one in the whole investigation of biomarkers of this infection. In addition, other objectives were considered to purify to the target enzyme (TAT) and to study its kinetic behavior and the in vitro effect of some schistosomicidal drugs (PQZ and MZR) as well as immunity drugs (immulant and immulant plus) on the kinetic behavior of this target enzyme.