الفهرس 
Pathophysiology of middle east respiratory syndromeOnly 14 pages are availabe for public view
 |  | from | 138 |  |  |
| | | from | 138 | | |
Abstract
Background: Middle East respiratory syndrome (MERS) is a respiratory disease caused by a newly recognized coronavirus (MERS-CoV). It was first reported in 2012 in Saudi Arabia and is thus far linked to countries in or near the Arabian Peninsula (United Arab Emirates [UAE], Qatar, Oman, Jordan, Kuwait, Yemen, and Lebanon). As of May 2014, two cases had been reported in the United States, both in men who had recently returned from Saudi Arabia.
Aim of the Work: The aim of the essay is to through light on the Middle east respiratory syndrome corona virus infection concerning it’s pathophysiology, diagnosis, prevention and ICU management.
Methodology: Middle East respiratory syndrome (MERS), also known as camel flu, is a viral respiratory infection caused by the MERS-coronavirus (MERS-CoV). Symptoms include fever, cough, diarrhea, and shortness of breath. As of June 20, 2015, 1,334 laboratory-confirmed cases of infection with MERS-CoV have been reported to the World Health Organization (WHO), including at least 471 related deaths. Coronaviruses are the largest of all RNA viruses, with positive single-stranded RNA genomes of 26-32 kb. The virus appears to have originated in bats. Transmission through contacts with animal e.g camel ,spread of MERS-CoV from person to person has been evidence of limited Spread.
Conclusion: Antiviral treatment can be actively considered since their efficacy has been confirmed in laboratory studies and they have shown some degree of efficacy in retrospective clinical studies. Mycophenolic acid, chloroquine, chlorpromazine, and loperamide have a demonstrated antiviral effect against MERS-CoV in laboratory tests.