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Abstract Delivering medicine to the general circulation through the skin is seen as a desirable alternative to taking it by mouth or by oral route. Patients often forget to take their medicine, and even the most faithfully compliant get tired of swallowing pills, especially if they must take several each day. Additionally, by passing the gastrointestinal (GI) tract would obviate the GI irritation that frequently occurs and avoid partial first-pass in activation by the liver. Further, steady absorption of drug over hours or days is usually preferable to the blood level spikes and troughs produced by oral dosage forms. These advantages are offered by the currently marketed transdermal products. |