الفهرس 
Review of LiteratureOnly 14 pages are availabe for public view
 |  | from | 122 |  |  |
| | | from | 122 | | |
Abstract
The aim of the present study is to determine and estimate the levels of CMV immunoglobulins (IgG &
IgM) in immunocompromised children suffering from leukemias & lymphomas.
One hundred and four ( 104) children (74 immunocompromised Patients & 30 control children) were
enrolled in this study from the Pediatric Clinics, Minia Oncology Centre. Patients and control
children were between 1- 15 years old with a mean age of8.6081 Ys (±3.9249 S.D.) and 7.5500 Ys
(±3.3650 S.D.) respectively.
All patients & control were subjected to full history taking, complete blood picture, liver
function tests and CMV markers (IgG & 1gM) by ”ELISA” technique.
We found no significant correlation between positive CMV IgG or positive CMV IgM and sex, residence
or socioeconomic level.
This study showed a prevalence of CMV infection among immunocompromised children, CMV IgG
positivity was present in 94.5% of cases and 87.5% of controls while CMV IgM positivity was present
in 18.9% of cases and 7.1% of control. This high prevalence is probably attributed to lack of
routine screening of blood for CMV which is recommended particularly in those groups of patients
who may require therapy with high doses of chemotherapy and/or B.M. transplantation.
A significant difference was found in CMV IgG levels between patients & control (P 0.0003). No
significant difference, however, was found in CMV IgM levels between both groups.
As far as historical data are concerned, a significant correlation was found between CMV IgG
positivity and blood transfusion (P 0.00002).
The results of this study concluded that immunocompromised children especially those taking blood
transfusion are more liable to have CMV infection.
The present study shows that, ELISA technique is highly sensitive method, easily to perform,
reliable, not time consuming (takes only few hours) and simple in its interpretation.