الفهرس 
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Abstract
The present study was designed to evaluate the diagnostic yield of plasma lactoferrin in comparison
to CRP and leucocytic count in children with various infections.
After thorough clinical examination, complete blood picture was performed to categorize patients
according to the number of neutrophils into two groups: Non-neutropenic (NNP) group (n=15). and
neutropenic (NP) group (n=15) and 10 health children as a control group. All the
study participants gave blood samples for determination of baseline <;;
reactive protein and lactoferrin levels. Patients gave two samples: on day of admission (S1)
and or. the 3’d day of admission (82).
There were 22 males and 18 females, with a mean age of 3.73±0.93 years and ranged between 2 and 5.2
years. There was a non-significant (P>0.05) differencG between patients and controls as regards sex
and age distribution.
There were 9 patients with chest infection, 11 patients with gastroenteritis, 2 patients with
pyelonephritis, 2 patients wJ!h multiple skin boils, 3 patients with tonsill.oadenoditis and 2
with” abscesses.
There was a significant (P<0.05) increase in mean TLC in NNP group and significant· (P”<0.05)
decrease of mean TLC in NP group compared to control count, with a significant incree:se in NNP
compared to NP group. Moreover, in NP group, lymphocyt s represented 45%, neutrophils were 45% and
other cell types were 10% with a significant increase in percentage and number of neutrophils in
NNP group in comparison to its rercentage both in control and NP group.
There was a non-significant (P<0.05) increase in serum CRP levels in both f\INP and NP groups
compared to’ control levels with a non-significant (P>0.05) decrease in levels determined in NP
group compared to NNP group.
Plasma lactoferrin levels in NNP group showed a significant (P<0.05) increase in 1st and 3’d days’
samples compared to control levels and to levels detected in NP group. Furthermore, plasma LF
levels showed a significant (P<0.05) increase on the 1st day sample compared to the 3’d day
sample.
There was a positive significant correlation (r=0.697, P=0.004) between plasma lnctoferrin and
se:rum CRP levels estimated on the 1st day sample in NNP, whereas the correlation despite being
positive it was non-significant (r=0.241, P>0.05) in NP group.