الفهرس 
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Abstract
Autism is a disorder of neural development characterized by impaired social interaction, verbal and nonverbal communication, also by restricted and stereotyped behavior. Our study objective was to measure some biochemical markers in autistic children and their matched control.
The importance of Autism, and hence the importance of the study, is attributed to its effect on 0.6 to 1% of the population worldwide.
Internationally, one of 88 children in USA develops any form of ASD and in Egypt, although the estimations differ but there is agreement that the disease is affecting same or higher than the global ratio.
This study is concerning potential biochemical markers in Egyptian children with autistic disorder. These biochemical markers are: glutathione peroxidase, isoprostane, nitric oxide, ceruloplasmin, and transferrin, Brain derived Neurotrophic Factor and zinc.
Subjects in the present study were classified into the following groups:
group I: included 15 healthy subjects aged between (3- 12) years among them 7 male and 8 female.
group II: comprised 15 mild autistic patients aged between (4 - 11) years among them 10 male and 5 female.
group III: covered 15 moderate autistic patients aged between (5 -9) years among them 11 male and 4 female.
group IV: included 15 severe autistic patients aged between (4 - 12) years among them 10 male and 5 female.
Based on the (CARS ), the autistic children was grouped into 3 groups mild, moderate and severe each group consist of 15 children males , females .the fourth group for healthy control.
Either ELISA or colorimetric method was used in order to determine the parameters of concern.
Results were recorded, analyzed using SPSS programmer.
Results of the present study showed that:
The level of glutathione peroxidase was significantly lower in autistic children comparing to control.
Isoprostane level was clearly higher in autistic children comparing to control.
The level of Nitric Oxide was significantly lower in autistic children comparing to control.
Both ceruloplasmin and transferrin showed a lower level in autistic children.
BDNF levels which were significantly elevated in autistic children comparing to control.
The level of Zinc was much lower in autistic children comparing to control.
BDNF, isoprostane, nitric oxide, ceruloplasmin and transferrin show highly significant performance in mild and moderate autistic patients while, in severe patients significant performance were observed between isoprostane, NO, ceruloplasmin and transferrin.