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Abstract The pathophysiology of CLI is complex and involves both macrovascular and microvascular pathology. Therefore it is not surprising that therapeutic modalities are multifold, spanning many health care specialties and requiring substantial institutional infrastructure to provide optimal patient care. The future of CLI treatment is as exciting as it is challenging. There is increasing focus on optimal wound care and prevention, adherence to proven medical therapies, improving revascularization results with novel endovascular and surgical techniques and devices, and ongoing investigation into promising therapies like therapeutic angiogenesis. Keywords Critical Ischemia Recent Management |