الفهرس 
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Abstract
Periodontal disease is a chronic infection of the periodontium affecting soft and mineralized tissue surrounding the teeth. Periodontal disease progression is associated with sub gingival bacterial colonization and biofilm formation that provokes chronic inflammation of soft tissues, degradation of collagen fibers supporting the tooth to gingival and alveolar bone and resorption of alveolar bone itself.
Osteopontin (OPN) is an O-glycosylated phosphoprotein that is synthesized in a variety of tissues and cells and secreted into body fluids. OPN is expressed in preosteoblasts, osteoblasts, osteocytes, OPN which identified in GCF and plasma known to act as an anchor for osteoclasts and one of the principal mediators of alveolar bone destruction in progressive periodontal disease.
The study include 40 patients divided into 4 groups,chronic gingivitis, chronic periodontitis , aggressive periodontitis and healthy control group. All groups receive periodontal treatment. The blood sample was collected from each patient for detection of plasma osteopontin levels.
The results show that the mean concentrations of osteopontin in plasma were found to increase progressively from health to periodontitis. The mean osteopontin levels in plasma were observed to be highest in the aggressive periodontitis group, followed by chronic periodontitis group and lowest in the healthy group, with intermediate values for the gingivitis group. Thus, the mean concentration of osteopontin increased progressively from health to gingivitis to periodontitis.
After periodontal treatment the OPN level was decrease in all groups confirming its active role in periodontal disease progression.