الفهرس 
Introduction & Aim Of The Work
IntroductionOnly 14 pages are availabe for public view
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Abstract
Magnesium sulfate (Mg) is an antagonist of N-methyl D Aspartate receptor (NMDA) which improves postoperative analgesia after intrathecaladministration as adjuvant to bupivacaine helping decrease morbidity, improve patient outcome. This study was conducted to assess the efficacy of addition of intrathecal magnesium sulfate to bupivacaine in neuroaxial block in patients goning to lower limbs orthopedic surgeries as regards of the onset & duration of sensory & motor block and postoperative analgesia.
Methods: 60 patients undergoing lower limb orthopedic surgeries were randomly divided into two groups,group l ( control group-30 patients ) : receive 3 ml Bupivacaine 0.5% + 0.75 ml saline .group ll (Mg group-30 patients) : receive 3 ml Bupivacaine 0.5% + 75 mg magnesium sulfate [.75 ml]. Demographic data(age, gender and weight ) andclinical data( Heart rate ,Mean arterial blood pressure and Arterial oxygen saturation) were collected.Onset and duration of sensory&motor block and also complications related to regional anesthesia were recorded.Visual analog scale (VAS)was recorded every two hours for first 8 hours then every four hours for the next 24 hours.Paracetamol 1gm I.V. will be given as rescue analgesia when VAS was >4 and time of administration will be recorded & total dose of rescue analgesia will be calculated.
Results:As regards for onset of Sensory& Motor block ,it was delayed in Mg group than control group.Duration of sensory & motor block was significantly increased in Mg group more than in control group.
Overall 24h VAS score of pain was significantly reduced in Mg group compared to control group.First analgesic requirement time for patients after surgery was significantly longer in Mg group compared to control group.Total analgesic requirement was significant lower in Mg group than in control group.As in Mg group26 patients request analgesia only twice, and only four patients request analgesia three times.But in control group 29 patients request analgesia three times and only one patient request analgesia twice.
As regard complication our study showed that there were insignificant differences between the two groups as regarding hypotension,nausea&vomiting.