الفهرس 
IntroductionOnly 14 pages are availabe for public view
 |  | from | 176 |  |  |
| | | from | 176 | | |
Abstract
beta thalassemia major is the most common hemoglobinopathies in our region with treatment of regular blood transfusion. It is characterized by abnormal hemoglobin synthesis, which result in decreased oxygen delivery to tissues, ineffective erythropoiesis and iron overload. Iron overload and hemosiderosis can cause organ damage and also it is the main cause of lung pathophysiology in thalassemic patients.
Neutrophil chemotactic and functional defects occurs in β-thalassemia major. IL-8is a novel chemotactic and activating peptide for neutrophils and can be detected in the circulation. IL-8 serum concentration were elevated in thalassemic patients, so it considered the inflammatory marker in their serum.
Lung impairment represents one of the complications of thalassemia major whose clinical picture can remain in subclinical form all life long, so follow up of β- thalassemia major patients regularly with IOS for early detection of small airway affection is needed.
Impulse oscillometry has been successfully used to measure lung function in children with high degree of sensitivity and specificity to small airway impairments. IOS measures of airway function and equivalent electrical circuit models of the human respiratory system have been developed to quantify the severity of the condition.