الفهرس 
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Abstract
Celecoxib is a non-steroidal anti-inflammatory drug (NSAID). It’s a cyclogenase-2 (Cox-2) specific inhibitor. It exhibit analgesic, antipyretic and anti-inflammatory activities. Celecoxib used in management of osteoarthritis, rheumatoid arthritis and dysmenorrheal pain. It’s also used in treatment of dental pain, swellings and inflammation. Celecoxib is particularly insoluble in water, which hinders its formulation into aqueous solution, also, this limits its dissolution prior to its absorption and, hence could limit its bioavailability upon administration. In the present thesis, various techniques were applied to improve the
dissolution rate of celecoxib, viz: preparation of the drug with different water soluble polymers and its interaction with cyclodextrins in solid state. Furthermore, the physicochemical characteristics of the prepared solid system were studied by differential scanning calorimetry (DSC), powder x-ray diffraction and infra-red spectroscopy (IR). Additionally, celecoxib was formulated into buccoadhesive tablets and stability of the prepared tablets was evaluated. As an integral part of this thesis, attempt was made to discuss the main mechanism(s) responsible for dissolution rate improvement of the drug.