الفهرس 
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Abstract
Stevia (Stevia rebaudiana Bertoni) plants have been used in many countries, as sweet herb. The plant have been used as either a sweetener or as a medicinal plant. The mutagenic activity of stevia has been assessed in this study. The assessement carried out through a several systems; a bacterial system (survival, prophage induction, transduction assays and antimutagenic potentiality) assays; teratogenic effect; histophathological examination and finally antioxidant activity. The amount of total phonelic compounds was 331.21 mg in 1 ml of stevia extract which leads stevia to have an antioxidant activity. The survival percentages did not changed greatly since at concentration of 10%, the killing effect was about 30% only, so the plant extract of stevia has no great influence on killing of bacteria. The obtained results of prophage induction assay showed a minor increase in prophage induction where as pfu/ml ranged from 1.58 up to 2.34×104 as a result of using the concentrations from 0.00 up to 20.00%. All the concentrations of stevia have been used in this study were not able to increase the transduction frequency significantly the fold increase than control ranged from 1.03 up to 1.34 only when 20% of stevia was used. The results of these assays proved that stevia has no mutagenic activity on bacterial assays, has no lesions on histopathological and has a lower effect on fetuses rats by using concentration of 15% on teratogenic examination only. Stevia also has a high content of phenols compounds which leads to a powerful antioxidant effect. Stevia has shown an antimutagenic activity in correlation to their antioxidant response. So it may be used as a natural sweetener source with no caloric.