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Abstract The precent study aimed to investigate the effect of using different herbs which were Elettaria cardamomum, Medicago sativa, Portulaca oleracea, Asparagus officinalis leaves and the blend of theses plant leaves at the level 10% on daily feed intake , body weight gain, feed efficiency ratio, some organ’s weight , serum lipid profile, liver and kidney functions of hypercholesterlemic rats. A total number of 42 female rats (118 +5g) were used in this study. Rats were divided into 6 groups and were fed on the hypercholesterlomic diet (2.5% cholesterol) for 3 weeks to induce hyperlipidemic as followes: group 1(control): (7 rats): Hypercholestrolemic rats were fed on the hypercholesterlemic diet only as control group. group 2: (7 rats): H.R. fed on hypercholestrolemic diet with 10% Portulaca oleracea leaves. group 3 :(7 rats): H.R. fed on hypercholesterolemic diet with 10%Elettaria cardamomum leaves. Group4: (7 rats): H.R. fed on hypercholesterolemic diet with 10% Asparagus officinalis leaves. group 5: (7 rats): H.R. fed on hypercholesterolemic diet with 10% Medicagosativa leaves. group 6: (7 rats) H.R. fed on hypercholesterolemic diet with 10% blend of the above plants. Total cholesterol, triglyceride, HDL, LDL, Liver functions and some kidney functions were determined in the serum. Moreover, liver, pancrease and heart were excised, rinsed, blotted, weighted and kept in formalion solution (10%) till histopathological investigation carried out. |