الفهرس 
IntroductionOnly 14 pages are availabe for public view
 |  | from | 296 |  |  |
| | | from | 296 | | |
Abstract
Biochemical evaluation of the potential anti-endotoxin effects of curcumin, rutin and resveratrol in a rat model of endotoxemia were investigated. Sixty four male rats, 8-10 weeks old and average body weight 180-220 g were used in the experimental investigation of this study. Rats were housed in separated metal cages and kept at constant environmental and nutritional conditions throughout the period of experiment. The animals were fed on constant ration and water was supplied ad- libitum. Rats were left 15 days for acclimatization before the beginning of the experiment. Induction of Endotoxemia: Escherichia coli (serotype O55: B5) is a gram negative rod (bacillus) in the family Enterobacteriaceae and is chosen and used in this study to induce endotoxemia. Moreover, endotoxemia was induced in rats by a single dose of intraperitoneal (i.p) injection of LPS (E.coli, serotype O55:B5) at a dose level of (200mg/ kg b. wt). Antioxidants compounds: The natural antioxidant compounds used in the present study were: Curcumin: Curcumin was freshly prepared by dissolved in 7% of dimethyl sulfoxide ( DMSO) solution and administered orally at a dose of (100 mg/kg b.wt./day) for 21 days. Rutin: Rutin was dissolved within propylene glycol solution and administered orally to rats at a dose level of (200 mg/kg b.wt) once daily for 21 days. Resveratrol: Resveratrol was freshly prepared in 5% Ethanol and administered to rats at a dose level of (10 mg/kg b.wt/ i.p.) daily for 7 successive days.