الفهرس 
OSTEOSARCOMAOnly 14 pages are availabe for public view
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Abstract
Background: Paediatric malignant bone tumours are rare cancers. Objectives: Evaluate the clinico-epidemiological aspects of paediatric bone tumour at Ain Shams University, Cairo, Egypt, from January 1, 1994 to July 1, 2016. Methods: Retrospective data analysis about clinico-epidemiological, survival analysis and musculoskeletal tumour society score (MSTS score). Results: The study included 37 patients with primary malignant bone tumour; male: female ratio 0.85:1, median ages of 11. The annual incidence of newly diagnosed cases was heterogeneous with overall incidence of 2.3%. Two cases had positive family history of malignancy; none had previously history of malignancy nor previously treated with radiotherapy. There is wide range of time lag until diagnosis due to misdiagnosis of three. 22 patients had Ewing sarcoma (ES) and 15 patients had osteosarcoma. Patients ES were statistical significance younger than those with osteosarcoma. Swelling was the most common presenting symptom, followed by pain. Femur was the most common affected site, followed by chest wall then tibia. MRI was the most accurate, 100% diagnostic, while CT was 72% diagnostic. Fifteen patients fulfilled the criteria for MSTS, most of them had excellent MSTS, and significantly affected by type of surgery. Most of ES patients treated with POG#9354/CCG#7942 protocols and osteosarcoma patients treated with CCG#7921 protocol. Limb salvage was the most common type for surgical local control. Eighteen patients are living while nine died. Most common cause of death was relapse, then complications of treatment. Infection was the most common complication of treatment. Seven patients relapsed and 23 were relapse-free. 1-year, 2-year, 3-year overall-survival of osteosarcoma were 93.3%, 40%, and 13.3% respectively and 1-year, 2-year, 3-year event-free-survival were 80%, 40%, and 13.3% respectively. Cases of ES: 1-year, 2-year, 3-year overall-survival were 77.3%, 40.9%, and 18.2% respectively and 1-year, 2-year, 3-year event-free-survival were 72.7%, 22.7%, and 18.2% respectively. Conclusion: Paediatric bone tumours are rare type of cancer and improve awareness of doctors about early diagnosis, referral, and treatment is crucial.