الفهرس 
Aim and plan of the workOnly 14 pages are availabe for public view
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Abstract
The master thesis include aim of the work and three main chapters
I- Aim of the work The work aimed to prepare and characterize new Schiff -base ligand and its metal complexes aiming to study their effects in the treatment of hepatocellular carcinoma (HepG-2 cell line).
II- Introduction This chapter includes an overview of previous researches for complexes of Schiff –base ligands and their application.
III- Experimental This chapter contains the chemical and instruments used in
Practical part of thesis as follow:
1) Preparation of the Schiff –base ligand and its metal complexes.
2) characterization of the ligand and its complexes using:
Physical techniques such as molar conductance and magnetic susceptibility
Elemental analyses (C, H, N, Cl and M).
Spectral techniques as IR, UV- Vis., 1HNMR, mass spectra and ESR measurements.
Thermal techniques as DTA. and TGA
3) Measurement of Antitumor activity
iv. Results and discussion
This chapter includes characterization of the ligand and its complexes. The ligand 2,2’-(1E,1’E)-(1,1’-(4,6-dihydroxy-1,3-phenylene) bis (ethan-1-yl-1-ylidene)) bis (azan-1-yl-1-ylidene) dibenzoic acid was prepared by refluxing with stiring equimolar amounts of 4, 6 diacetyl resorcinol (10, 0.051 mol) and anthranilic acid (7.06, 0.051 mol) in ethanol (100 cm3) for 2 h. The reddish brown product obtained was filtered off, washed several times with ethanol and dried in vacuum over P4O10.
The reaction of the ligand with Cu(II), Ni(II), Mn(II), Bi(III), Co(II), Zn(II), Cd(II), Pb(II), Cr(III), Al(III), and Ag(I) complexes have been synthesized and characterized by (1H-NMR, mass, IR, UV-VIS, ESR) spectroscopy, (magnetic moments, conductance) measurements, (elemental and thermal) analyses. The analytical and IR data show that, the ligand behaves as neutral bidentate or hexadentate or monobasic tetradentate or dibasic hexadentate. Molar conductances in DMF indicate that, the complexes are non-electrolytes. ESR spectra of solid Cu(II) ) with covalent y2-x2ture show axial type (dcomplexes at room temperabond character in an octahedral environment. However, Co(II) and Mn(II) complexes showed isotropic type. Some complexes showed inhibitory activity against hepatocellular carcinoma (HepG-2 cell line). Also, the Cd(II) complex (11) showed a high potency of inhibition (91.38%) at 50μg/ml against HepG-2 cell line, (81.79%) at 25μg/ml, (55.32%) at 3.125μg/ml and (18.18%) at 1.56 μg/ml compared with a standard drug. Cd(II) complex (11) demonstrated the highest potency inhibition activity .9) μg(2. 502 cell line with IC-among all tested compounds against HepG.