الفهرس 
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Abstract
One of the most serious complications associated with premature birth is neonatal sepsis. There are various diagnostic markers of sepsis like C- reactive protein, cytokines. Serum Endocan concentration may be a useful adjunct test of sepsis. Endocan, also called endothelial cell-specific molecule-1, is secreted from pulmonary and kidney vascular endothelial cells. Endocan can be acknowledged as a good marker of endothelial and multiple organ dysfunction in sepsis. The aim of this study was to evaluate the serum endocan levels in the preterm neonates suffering from sepsis. This study was carried out at Neonatal Intensive Care Unit (NICU) of Tanta University Hospital, this study was conducted on 30 septic preterm neonates and 30 healthy preterm neonates were enrolled as control group. Our results showed that blood culture in patients which was po4sitive in 24 cases (80%), klebsiella was the dominated organism isolated from blood (33.3%), followed by pseudomonas(16.7%), staph aureus (16.7%), Enterobacter (6.7%) and MRSA(6.7%). Serum endocan levels were significantly higher in preterm septic neonates (0.245 ± 0.123) than in controls (0.029 ± 0.006). we concluded that serum endocan levels were significantly higher in preterm septic neonates than in controls, Sensitivity and specificity of serum endocan in septic neonates was 85%, 90% respectively. Serum endocan can be used for early diagnosis of neonatal sepsis.