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Abstract The mammalian oviduct or fallopian tube has fundamental roles in gamete transport, fertilization, and early embryo development that are facilitated by ciliated and secretory epithelial cells lining the lumen. Several experimental models had shown that oviductal development is regulated by the ovarian sex steroid hormones estrogen and progesterone. Sex steroids are involved in the control of gamete transport and ciliary activity in the fallopian tube. Estradiol (E2) treatment accelerates ovum transport from 1 h to 24 hours in rats, facilitates sperm migration and induces adhesion of spermatozoa to the oviductal epithelium. Aim: To study the effect of clomiphene citrate and isoflavone administration on the structure of the fallopian tube of prepubertal and adult albino rats to determine safe usage of clomiphene citrate in female infertility. Fallopian tube is a dynamic, steroid responsive tissue has fundamental roles in gamete transport, fertilization, and early embryo development. Clomiphene citrate (CC) is non steroidal synthetic hormone with estrogenic effect has been the first line therapy for induction of ovulation in women with anovulatory infertility. Phytoestrogens are a group of non- steroidal compound of plant origin that present structural and functional similarities with17 β estradiol. Isoflavones, are the most widely known category. There are different mechanisms of action of isoflavones accepted, although they may be considered as selective modulators of estrogen receptor. |