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Abstract Due to scientific and public concern about the environment pollution, environmentally friendly practices have been introduced in different areas of society and research. Green analytical chemistry (GAC) is a rapidly growing and established field. It is based on principles overlap with the sustained development ultimate goals. It concerns mainly with the development of environmentally friendly analytical procedures and sample preparation techniques that minimize consumption of hazardous reagents and solvents, and maximize safety for scientists and the environment. This ambitious and quite new approaches not only occurring in academia but also in industrial and pharmaceutical environment. The majority of USP methods and methods that have been approved by the food and drug administration (FDA) use organic solvents, corrosive and toxic chemicals such as acetonitrile, tetrahydrofuran, benzene, chlorinated reagents, etc. that are hazardous pollutants and/or carcinogenic, with no other options currently available. The aim of this work is to develop and validate greener analytical methods, compared with the reported or official methods without compromising efficacy through different strategies such as modifying already existing method or replacing them with new techniques, making it possible to cut or dramatically reduce the amounts of reagents and solvent consumed, switching to more benign solvent and waste generated. |