الفهرس 
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Abstract
In this article, N-substituted chitosan derivatives were synthesized through condensation with a number of selected aryl and heteroaryl aldehydes; a number of previously prepared aldehydes were employed: (ethyl-2-formyl-5-methyl-4-furouate, ethyl-5-formyl-2-methyl-1H-pyrrole-3-carboxylate, 1-(2-phenyl-2H-1, 2, 3-triazole-4-yl)ethanone, as well as 2-nitrobenzaldehyde, and 4-bromobenzaldehyde in the reaction of chitosan and aldehydes. the synthesis of the amino derivatives has been carried out by reductive amination with sodium borohydride as reducing agent.
The structures of the prepared compounds were characterized by (FTIR, 1HNMR, and XRD). The antimicrobial activity of the prepared chitosan shiff’s base (CSB) derivatives were investigated against four types of bacteria: Straphylococcus aureus (RCMBA 2004) and Bacillissubtilis (RCMBA 6005) as Gram-positive bacteria and against Pseudomonas aeruginosa and Escherichia coli (RCMBA 5003) as Gram-negative bacteria, and two crops threatening pathogenic fungi (Aspergillus fumigates (RCMBA 06002), Syncephalast rumracemosum (RCMB 05098)), the results indicated that the antibacterial and antifungal activities of the investigated derivatives are very promising. Also, different concentrations of the triazolo-shiff’s base derivative that showed the best results with antimicrobial tests, were used for cytotoxicity screening against with antimicrobial tests, were used for cytotoxicity screening against Human Breast Adenocarcinoma Cells (MCF7), Human Colon Carcinoma Cells (HCT116) and Human Hepatocellular Liver Carcinoma Cells (HepG2), the obtained data revealed that the examined compound have an excellent cell growth inhibitory effect on the cell lines as compared to standard.
In conclusions; some of new Chitosan Schiff’s bases have been synthesized. Their structures were approved by standard methods. Evaluations of their anti-bacterial, anti-fungal, and cytotoxicity properties have been studied.