الفهرس 
The intestinal absorptionOnly 14 pages are availabe for public view
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Abstract
This thesis presents enhancement techniques used to improve intestinal absorption of eprosartan mesylate. Eprosartan mesylate was analyzed using a validated RP-HPLC method of analysis using Agilent HPLC apparatus and a separating SB–C8 column with a mobile phase composed of 0.2% v/v diluted ortho-phosphoric acid in highly purified water and acetonitrile at a ratio of 68:32 (v/v), respectively. The general introduction describes the barrier nature of the intestine against drug absorption. It includes the mucous, the capillary wall, the tight junctions and the apical and basal cell membrane. Also enhancement of intestinal techniques is included, e.g. nano emulsions, self emulsification and inclusion complexation. LBDDS were reviewed. The in situ rabbit technique adopted in the thesis was described briefly. Eprosartan mesylate properties were reviewed. Finally, CD inclusion complexation was summarized. One chapter is dedicated to RP-HPLC analysis method of the drug showing the chromatographic optimum conditions and the validation of the method through assurance of system suitability, constructed calibration curve, linearity and range, accuracy, precision limit of quantitation, limit of detection. The absorption enhancement of EM from nano emulsion formulated through a low energy method: self nano emulsification is illustrated. Self nano emulsified DDS was efficiently developed using Labrafil, Laurogol, Tween 80 and absolute alchohol as a co solvent. Assessment of the drug delivery system is done both visually and by UV-VIS spectrophptometer. Absorption enhancement was assured using in situ rabbit technique by comparison with an aqueous pH adjusted solution of the drug as a control.