الفهرس 
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Abstract
Chronic renal failure or chronic renal disease (CRD) is a progressive loss in renal function over a period of months or years. It is differentiated from acute kidney disease in that the reduction in kidney function must be present for over 3 months(USRDS 2012).
In Egypt; ESRD is growing by 100% annually; the estimated annual incidence of ESRD is around 74 per million and the total prevalence of patients on dialysis is 264 per million, also there are 90,000 patient die each year because of kidney failure (Ahmed et al., 2010).
Uremic pruritus is the most common cutaneous abnormality in patients with CRF. Its prevalence among CRF patients was (19-90%) (Pico etal., 1992). In Egyptian patients with CRF on hemodialysis theprevalence of pruritis was 55% (Sultan et al., 2010).
Uraemicpruritus is unrelated to sex, age, duration, cause of dialysis, a list of unproven suggestions for pruritis include : dry skin; mast cell proliferation; Th1 cytokines; secondary hyperparathyroidism; disturbed balance between μ-opioid and κ-opioid receptors; substance P; increased skin ions Ca, Mg, PO; abnormal transmission via the spine (Jovanović 2014).
Nerve growth factor is a neurotropic polypeptide necessary for the survival and growth of some central neurons, as well as sensory afferent and sympathetic neurons (Mastuda et al., 1998).
It has been found that in AD patients increased levels of NGF in keratinocytes and infiltrating leukocytes which were related to disease severity(Dou et al., 2006).Skin from patients with prurtigonodularis also have increased presence of NGF which is primarily found in infiltrating leukocytes(Johansson et al., 2002).
There were no previous studies that investigated the expressions of NGF and its receptor TrKA in CRF patients with uremic pruritus on hemodialysis.
The aim of this case controlled study was to investigating the expressions of NGF and its receptor TrKA in CRF patients with pruritus on hemodialysis and correlated the pattern of expressions with an itch score.
A significant increase in the expressions of NGF and TrKA in CRF patients with pruritus on hemodialysis compared to the healthy control participants and also there was significant correlation between degree of expressions of NGF and TrKA and 5-D itching score could be the cause of initiation and maintenance of pruritus in CRF patients with pruritus on dialysis.