الفهرس 
DEFINITION OF I NFERTILITYOnly 14 pages are availabe for public view
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Abstract
Introduction: Most women with uterine factor infertility have today the possibility to become pregnant with the development of human uterus transplantation. Several trials had been conducted in sev¬eral animal spe¬cies before performing the procedure in humans.
Aim: The present study aimed to provide an experimental clinical trial of uterine autotransplantation in dog and assessment of the vascularity of transplanted uterus.
Methods: Ten female dogs underwent hysterectomy for uterine autotransplantation including the uterus with the connected blood vessel pedicles including uterine vessels and internal iliac vessels, cervix, upper part of vagina and the proximal portion of two uterine horns. Macrovascular reanastomosis was performed by end-to-end anastomosis of the internal iliac vessels. Four weeks later, the uterus was removed and examined for signs of necrosis and doing histopathological examination.
Results: The main outcome measures were: (i) Three animals were dead due to intraoperative and postoperative complications as hemorrhage and infection. (ii) Three dogs with failed transplantation showed signs of necrosis and abnormal histological examination. (iii) Four dogs showed successful transplantation.
Conclusion: This study demonstrated the feasibility of uterine autotransplantation using a macrovascular patch technique in dogs. Accumulation of basic experimental data in non-human primates is required prior to human trials.
Keywords: infertility, uterine factor infertility, auto uterine transplantation.