الفهرس 
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Abstract
Benign prostatic hyperplasia (BPH) is the most common benign tumor in men refers to regional nodular growth of varying combinations of glandular and stromal proliferation that occurs in almost all men who have testes and who live long enough (Speakman, 2004) .
The prevalence of clinical BPH in an individual community in men ages 55 to 74 years may vary from 5% to 30% (Verhamme et al., 2002). .
The aetiology of BPH is seems to be multifactorial and endocrine controlled and additional investigations have demonstrated a positive correlation between levels of free testosterone and oestrogen and the development of BPH (Roehrborn et al., 2002). .
Complex forces contribute to the pathophysiology of BPH and production of the LUTS observed in men as hyperplasia, role of androgen, role of oestrogen, regulation of programmed cell death, growth factors and genetic and familial factors (Roehrborn et al., 2002).
BPH diagnosed clinically, patient complains of hesitancy, abdominal straining while voiding, interrupted flow, nocturia, day time frequency and incontinence (O’Leary et al., 2003).
DRE is an important examination in men with LUTS for two reasons. Firstly, it can help to determine the co-existence of prostatic carcinoma. Secondly, it enhances the capacity to estimate prostate volume, and in this way may assist in choosing the right treatment. Also it assesses the presence of rectal malignancy and evaluates the anal sphincter tone (Koch et al., 1996) .
The main goal of treatment of BPH is to relief LUTS and decrease incidence of BPH complications as urinary tract infection, urinary retention, stones and chronic renal failure (Roehrborn, 2006).
Our study aimed to compare the efficacy and tolerability of the doxazosin-GITS formulation versus tamsulosin in treating patients with benign prostatic hyperplasia (BPH).
This study includes 60 patients with BPH subjected to complete history taking, general and abdominal examination, DRE, laboratory investigation, peliv-abdominal US and measuring post voiding residual urine.
This study compromised of four phases; a 2-week washout phase and a 16-week active treatment three phases. Qmax, urine volume, blood pressure and heart rate, answered IPSS questionnaire and recording the side effects occurred with each drug and the results of the two groups were compared.
Our study revealed that treatments with tamsulosin and doxazosin-GITS were both well tolerated, but treatment with doxazosin-GITS was significantly more effective than tamsulosin in relieving LUTS with good tolerability and improvement which provide increased patient compliance with the medication, thus maintaining the improvement in LUTS.