الفهرس 
OncogenesOnly 14 pages are availabe for public view
 |  | from | 199 |  |  |
| | | from | 199 | | |
Abstract
Background: Breast cancer is the commonest cancer affecting women. A family history of breast cancer increases a woman’s lifetime risk of developing the disease. a woman in the developed world has a lifetime risk of developing breast cancer of approximately 9:11%. In 2009. Aim of the Work: To highlight genetics of breast cancer. To show the different surveillance and management of hereditary breast cancer. Conclusion: It is important to realize that the cancer history of both the maternal and paternal lineage is important. The high-risk breast cancer susceptibility genes include BRCA1, BRCA2, PTEN, TP53, LKB1/STK11and CDH1, with relative lifetime risks higher than 4 (but generally much higher at young ages). The CHEK2, TGF1, CASP8 and ATM genes belong to the low- to moderate-risk breast cancer susceptibility genes.
Key words: breast cancer, hereditary, susceptibility genes