الفهرس 
• Non-Alcoholic Fatty LiverOnly 14 pages are availabe for public view
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Abstract
Introduction: Fatty liver refers to many diseases characterized by excessive fat accumulation in the liver either alcoholic or non-alcoholic in origin. Methionine is a well-known chemical which is used to experimentally induce hyperlipidemia and fatty liver. Curcumin has been shown to reduce the risk of atherosclerosis and hyperlipidemia. Oval cells are hepatic progenitor cell found near the canal of hering appear in many acute liver diseases. Aim: of this study is to evaluate the effect of curcumin on the regenerative capacity of the liver in experimentally induced non alcoholic liver disease (NAFLD) in adult male albino rats with reference to oval cells.
MATERIALS AND METHODS: Fifty adult male albino rats with average weight 200-250 gm were used in this study. The animals were randomly divided into 5 groups, 10 rats each as following: group I:control group. group II: each animal was given equivalent amount of normal saline via gastric tube for 4 weeks then received curcumin orally in a dose of 200mg/kg/day for 4 weeks. group III: each animal received methionine orally in a dose of 1 gm/kg/day for 4 weeks to induce NAFLD. group IV:each animal received methionine for 4 weeks as in group III then received curcumin. group V (Recovery) each animal received methionine for 4 weeks then left for recovery for 4 weeks. Results: Methionine administration resulted in a picture of irreversible NASH in rats. Meanwhile administration of curcumin alleviated the hazardous effect of methionine on hepatocytes. Oval cells were detected only in the affected liver of rats of group III.
Conclusion: The results of the present study revealed that curcumin administration was proved to ameliorate the structural changes caused by methionine. Moreover, oval cells were detected only in the injured liver of methionine treated rats (group III). This might be an indicative of their potential role in regeneration of the injured liver