الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Pyridine constitutes an integral part for many biologically active natural products in living tissues such as niacin and its amide derivative nicotinamide. Pyridine derivatives and pyridine-fused ring systems represent a class of heterocyclic compounds that possess diverse biological activities such as anticancer, antimicrobial, anticonvulsant, anti-inflammatory, antiviral, antimycobacterial and antioxidant.
Pyridine derivatives incorporating isonicotinic acid hydrazide pharmacophore have a great biological and medicinal significance; its therapeutic efficacy against mycobacteria is related to their ability to inhibit bacterial cell wall biosynthesis.
In addition to their biological importance, pyridines are valuable for the preparation of fused ring compounds, such as thiazolopyridines which is one of the important ring systems that has drawn the attention for its diverse biological activities.
Motivated by these facts and as a continuation of our research on heterocyclic chemistry aiming to find new structure leads which might be of value for development of new more potent antimycobacterial agents, with higher safety profile, the present investigation was directed to design, synthesize and biologically investigate a new series of pyridine derivatives as antimycobacterial and antioxidant agents. In addition substitution patterns were varied in order to achieve structure-activity relationship knowledge.
The present thesis comprises the following chapters:
Chapter 1: Introduction
It represented a brief literature survey on biologically active substituted pyridine derivatives, exhibiting antimycobacterial and antioxidant activities focusing on the recent researches.
Chapter 2: Research objectives
It clarified the goal of the present work and the rational upon which the newly suggested compounds were designed.
Chapter 3: Results and Discussion
This chapter dealt with results and discussion of the molecular modeling, synthesis and biological evaluation of the target compounds. This chapter divided into three parts.