الفهرس 
Turner SyndromeOnly 14 pages are availabe for public view
 |  | from | 166 |  |  |
| | | from | 166 | | |
Abstract
Turner syndrome (TS), in which there is loss of all or part of one sex chromosome occurs in one in 2500 born females and is associated with short stature, and ovarian failure with sexual infantilism and infertility.
Serum AMH level is thought to be a predictor of the follicle reserve, with high AMH levels associated with high number of remaining ovarian follicles. The decline in serum AMH levels precedes the changes in traditional markers for ovarian reserve, such as FSH, inhibin B and E2. Assessment of serum AMH, also at a young age, is indicative of ongoing follicular development. AMH levels of TS patients are lower but to some level overlapping with normal measurements of healthy females.
This cross sectional study was conducted on 50 patients with TS, whose ages ranged from 4.5 to 20 years, with a mean of 13.56±3.38 years; patients were collected by random sampling technique during the period from February 2013 to February 2014, from Nile Hospital, Egyptian Health Insurance. Patients were compared to 40 age - and sex- matched healthy subjects serving as controls who were collected from the pediatric outpatient clinic from the same hospital.
Our results showed that, height SDS was significantly lower in TS patients than controls (p=0.000).Weight SDS was significantly higher in TS patients than controls (p=0.000).
Patients with Tanner B1 were (40 %) in age range 5.11 – 16.4 years, B2 were (30%) in age range 10 – 20 years, B3 were (20%) in age 11.4-18.9 years, B4 were (10 %) age range 13.7 -18.8 years. That means that Turner patients reach Tanner breast stages in older age when compared to normal population. Advanced Tanner breast stages were significantly higher among controls (p=0.000).
There were significant negative correlations between AMH and each of FSH (p=0.000), and LH (p=0.034) levels.
There were significantly higher AMH levels among controls than cases (p=0.000), and significantly higher FSH (p=0.000) and LH (p=0.015) levels among cases than controls, and measurable serum AMH levels were detected in 10 (20%) of patients.