الفهرس 
Childhood Obesity and Nonalcoholic Fatty Liver DiseaseOnly 14 pages are availabe for public view
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Abstract
Abstract
Comparison between obese patients and control group revealed significantly higher serum visfatin levels in patients. Higher visfatin levels were found among patients with dyslipidemia, NAFLD and/or elevated ALT as well as those with steatosis. Moreover, serum visfatin was gradually increased in relation to NAFLD grades till reaching the highest levels in NAFLD grade II. In addition, increased visfatin levels were associated with significant degree of fibrosis and steatosis being higher in METAVIR score F3 and steatosis stage S3.
ROC curve analysis revealed that visfatin cutoff value 18 ng/mL could significantly detect the presence of NAFLD among obese patients with 83.9% sensitivity and specificity of 71.4%.
There were significant positive correlations between serum visfatin and each of BMI SDS, waist circumference, waist/hip ratio, ALT, total cholesterol, liver stiffness.
Liver stiffness was significantly higher in patients with dyslipidemia, heptomegaly, NAFLD, steatosis as well as those with both NAFLD and elevated ALT. It was also elevated in relation to increased grade of NAFLD. ROC curve analysis revealed that liver stiffness cutoff value 4.5 KPa could significantly detect the presence of NAFLD among obese patients with 63.3% sensitivity and specificity of 73.5%. Liver stiffness was positively correlated with serum creatinine, LDL-cholesterol and liver span.
Keywords: Visceral adipose tissue- Peripheral blood-Computed tomography - Analysis of Variance