الفهرس 
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Abstract
The development of in-situ gel systems has received considerable
attention over the last few years. In the last few years, increasing number
of in-situ gel forming systems have been investigated to provide sustained
drug delivery.
Drugs that are easily absorbed from the GIT and having a short
half-life like buspirone HCl (BH) are eliminated quickly from the blood
circulation. To avoid these problems, oral controlled drug delivery
systems have been developed as they can release the drug slowly into the
GIT and maintain a constant drug concentration in the serum for a longer
period of time; therefore, they enhance the bioavailability of drugs. Also,
the intranasal route has been considered as a viable alternative for drugs
which suffer from extensive first pass metabolism like BH. This route is
also having an added advantage of direct delivery of drugs to the brain
when the site of action is in the brain. Buspirone HCl-loaded niosomes
were also formulated in order to increase the nasal absorption of BH.
The aim of this thesis is to formulate BH into oral and nasal
niosomal in-situ gels to solve the previously mentioned problems.