الفهرس 
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Abstract
Preeclampsia (PE) is a pregnancy specific disorder which is
characterized by high blood pressure and large amount of protein in urine
usually in the 3rd trimester of gestation and get worse over time. It affects 3
- 17% of pregnancies worldwide and entails serious consequences for both
the mother and the fetus.
Treg cells constitute a T helper lineage that is derived from thymus
(natural Treg cells) or is induced in the periphery (induced Treg cells). Treg
cells are enriched at the fetal-maternal interface, showing a suppressive
phenotype. In contrast, Treg cells are not increased in the circulation of
pregnant women, and the suppressive capacity is similar to that in nonpregnant
women. However, aberrations in Treg frequencies and functions,
both systemically and in the uterus, may be involved in complications of
pregnancy.
Our case-control study was conducted on 50 subjects of pregnant
women divided into two groups. group (1): case group included 30
pregnant women with preeclampsia (PE). group (2): control group
included 20 healthy pregnant women who matched the group (1) for age
and mode of delivery. Any pregnant woman complicated by clinical
chorioamnionitis, any infectious disorder or preexisting clinical disorders,
such as chronic hypertension or renal diseases before pregnancy was
excluded from the study.
Cord blood samples were collected from both groups and evaluated
by flow cytometry for CD4+CD25highFOXP3+ Treg cells.