الفهرس 
? Blood Component TherapyOnly 14 pages are availabe for public view
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Abstract
Red blood cell transfusion is an important and frequent component of neonatal intensive care. The most frequent indications for blood transfusion in newborn are the acute treatment of perinatal hemorrhagic shock and the correction of anemia of prematurity.
Sick neonates are one of the most heavily transfused groups of patients in modern medicine. However, despite considerable research, most neonatal transfusion practices remain opinion-based rather than truly evidence based.
The safety of transfusing RBCs after longer durations of refrigerated storage was identified as “the most critical issue facing transfusion medicine”.
Growing evidence indicates that an imbalance between oxidative stress and antioxidant defense mechanisms play an important role in the onset of many diseases during neonatal period.
The damaging effect of reactive oxygen species (ROS) is limited by the numerous cellular antioxidant defense mechanisms in the body including enzymes such as Superoxide dismutase (SOD) and Catalase (CAT), non-enzymes such as vitamins (A, C, E) and carotenoids and other antioxidant minerals (Copper, Ferritin, zinc, manganese, selenium).
This study was a randomized controlled trial that was conducted on 65 term and near-term neonates (35≥weeks gestation).
The patients were randomized into one of two groups, group A included 31neonates who received fresh blood within 7 days of donation and group B included 34 patients who received packed RBCs units collected ≥ 7 days prior to transfusion but yet within the standard universally accepted range.
Samples were taken from neonates prior to blood transfusion and 2-3 hours post-transfusion. TAC, MDA and trace elements serum Copper (S.Cu), Zinc (S.Zn), Calcium (S.Ca), Magnesium (S.mg), S.NTBI and Selenium (S.se) were measured pre and post transfusion.
Our results showed that though fresh blood transfusion though had no clinically appreciated advantage over older blood, yet it was associated with more superior biomarkers profile. This was evidenced by lower TAC levels among group B (blood units older than 7 days) compared to group A. A significant negative correlation between post-transfusion TAC levels and age of donated blood in days was also found among patient groups collectively.