![]() | Only 14 pages are availabe for public view |
Abstract Toxoplasmosis is caused by T. gondii protozoan and is estimated to infect one-third of the world’s human population. Children born with toxoplasmosis can be suffered from intellectual disabilities, convulsions, spasticity, cerebral palsy, deafness particularly in untreated children or those treated for a short period. Cerebral Toxoplasmosis has been reported to cause seizures in about 25% of infected cases by producing diffuse encephalitis or localized lesions. Toxoplasma infection is implicated to have an association with epilepsy either as a cause or a potential risk factor for its occurrence. Hearing impairment has been reported in about 20% of the congenital toxoplasmosis cases. The present study was carried out with a total of sixty cases, twenty patients with cryptogenic epilepsy, twenty patients with nerve deafness and twenty patients with cerebral palsy from those attending Benha university hospital and Shebin El-Kom teaching hospital either inpatient or outpatient clinic of pediatrics neurology and audio clinc and twenty children sex & age matched with the patient groups served as control group. The age group was between 1 year and 16 years old. Each child included in this study was subjected to full history taking, including main complain of the patient, socioeconomic status, history of contact to animals. The demographic and life style information was obtained through a survey questionnaire and clinical examination according to the standard clinical sheet with special stress on the neurologic examination. Summary and Conclusion - 122 - The study results showed that no significant difference between the studied groups regarding the socio-demographic characters but the percentage of epileptic patients residing rural areas was higher than that residing urban ones. Also our results showed that there was statistically significant increase in history of contact to animal in cryptogenic epilepsy group comparing to control group (P= 0.025*) but there was no significant increase in history of contact to animals among nerve deafness and CP groups compared to control group. As regard cooking preference there was statistically significant increase in history of consuming well cooked meat in cerebral palsy group comparing to control group (p= 0.047*) but there was no significant among epilepsy and nerve deafness groups comparing to control groups. Our results revealed that there was no significant difference between the studied groups regarding to consanguinity. We found a statistically significant association between T. gondii infection and cryptogenic epilepsy. The anti Toxoplasm IgG positive cases represented 40% of the cryptogenic group, 10% of the control group with (P = 0.028*). |