الفهرس 
Anatomy of Colon, Rectum andOnly 14 pages are availabe for public view
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Abstract
Introduction Hirschsprung’s disease is a congenital defect manifested by the absence of parasympathetic ganglion cells in the distal colon. Patients have a lack of peristalsis and a loss of involuntary relaxation of the internal anal sphincter, which leads to functional bowel obstruction. Severe constipation and mega-colon proximal to the area of affected bowel can occur, and can cause life-threatening enterocolitis if left untreated. The rectum is always involved, with 80% of cases limited to the rectosigmoid colon.
Infants with Hirschsprung’s disease will have corrective surgery within the first few weeks of life or months later, depending on their overall health, and degree of colonic distension.
Hirschsprung’s disease is diagnosed in the first few months of life in about 80% of patients, but in about 20% of cases, the diagnosis is made beyond the newborn period.
Aim of the Work: The aim of this essay is to spotlight the different modalities in diagnosis and treatment of Hirschsprung’s disease.
Conclusion: Hirschsprung disease is a heterogeneous disease that is caused by a variety of genetic mutations, and has a wide range of presentations and severity. The diagnosis is suspected on the basis of neonatal intestinal obstruction, chronic constipation, or enterocolitis, and is confirmed on rectal biopsy. Surgical correction is done using one of several reconstructive techniques. Most cases can be successfully performed without a preliminary colostomy or a major abdominal incision. Many patients have enterocolitis or functional problems with obstructive symptoms or soiling after surgery, but in most cases these resolve with appropriate diagnosis and treatment over time. The pediatrician or primary care physician can play an important role in the ongoing management of these children.