الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
 |  | from | 73 |  |  |
| | | from | 73 | | |
Abstract
Proliferative diabetic retinopathy (PDR) is the angiogenic response of the retina to extensive capillary closure. New vessels grow at the interface of perfused and non-perfused retina; these fragile new vessels may bleed leading to vitreous hemorrhage and fibro vascular proliferation. It is the most frequent cause of blindness in industrialized countries, affecting 30% to 50% of the individuals with diabetes.
Pan-retinal photocoagulation has been the gold standard in PDR treatment since it was proven effective in the Diabetic Retinopathy Study.
Completion of PRP in a single session is less common due to the need for more local anesthesia to manage the higher pain levels and the higher incidence of side effects such as macular edema. However, completion in multiple sessions requires a physician to spend more time per patient, requires the patient to make multiple visits to the hospital, and increases the economic burden of treatment. It also means that treatment remains incomplete in more patients due to poor patient compliance and dividing treatment into multiple sessions may delay the onset of treatment effect, particularly in high-risk PDR eyes.
The consensus among previous studies is that single session therapy with MSL results in shorter treatment time and less pain compared to single spot multiple sessions therapy.
This is a prospective interventional study aiming to evaluate the effect of one session versus multiple sessions of pan retinal photocoagulation upon macular thickness, RNFL thickness and GCL thickness.
This study was conducted on 30 eyes belonging to patients of both genders and various age groups. History taking, ophthalmological examination fluorescein angiography and Spectral domain optical coherence tomography (SD-OCT) were performed on all patients prior to intervention.
Laser treatment was performed after written informed consent to the treatment protocol was obtained, Diode laser (577nm) was applied as follows: A spot size of 200 microns was chosen. The power adjusted ranging from 180-260mw with duration of 150ms, an interval in multiple sessions group of 250ms and a pattern mode in one session group (3x3, 4x4 and 5x5).
Follow up was conducted at 3 visits at 1 week , 1 month and 3 months. During each of these visits. Macular thickness, RNFL thickness and GCL thickness were measured by OCT. BCVA was measured pretherapy and 3 months after therapy.
There is no statistically significant change in macular thickness, RNFL thickness and GCL thickness before and after PRP without any statistically significant difference in these changes between one session group and multiple sessions group.