الفهرس 
Introduction and Aim of the WorkOnly 14 pages are availabe for public view
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Abstract
The presence of microbial contaminants in non-sterile pharmaceutical preparations was not only found to cause spoilage of numerous products but was also proved to be a potential health hazard to the consumer. Accordingly, non-sterile preparations have to pass microbial bioburden tests and tests for the absence of certain specified indicator pathogens. The objective of this study was to test the microbiological quality and challenges for microbial contaminants recovery and detection of specified indicator pathogens of some herbal pharmaceutical preparations available in the Egyptian market.These study evaluated the microbiological quality of herbal teas and syrups, drops in according to international pharmacopoeias (USP, 2006; EP, 2014), and the preservative efficacy the syrups and drops according to USP (2006).A total 205 products divided into two groups, the first group included herbal teas as 32 products (three batches from each product) represent different manufacture in the Egyptian market, the second group included 109 syrups and drops in Egyptian market containing herbal ingredients.These herbal products were examined by determination of total aerobic bacterial count and yeast and mold count using surface spread method and membrane filter method. The products were test for detectionof specific microorganism (Enterobacteriace, Salmonella spp., Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa). The syrups and drops were subjected to preservative efficacy test to determine their microbial quality.
Out of 32 herbal teas, the study showed that seven products (21.8%) were not complying with USP (2006) requirements as they contained high yeast and mold count. Two products (6.25%) were not complying with USP (2006) requirements as they contained E. coli. Four products (12.5%) were not complying with EP (2014) requirements as they contained S. aureus.
For syrups and drops only two (1.8 %) of the products were not complying with USP (2006) requirements as they contained high counts of yeast and mold. Four products (3.6 %) contained S. aureus were not complying with EP (2014) requirements.
Most of tested syrups and drops samples were found to be with good microbiological qualities as they were complying with the requirement of United State Pharmacopoeia (2006) and European Pharmacopoeia (2014).
For preservative efficacy test, only 31 products could pass the challenge test, while the remain product were not complying with USP (2006) requirements.