الفهرس 
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Abstract
Psoriasis is a chronic immune mediated condition affecting about 2 % of the population worldwide that causes the rapid build-up of skin cells. Typical psoriatic scales are whitish-silver and develop in thick, red patches.
Psoriasis is associated with deranged iron status characterized by depleted iron stores with concomitant unmet cellular iron requirements.
Hepcidin is acknowledged as the key regulator of iron metabolism. Inflammatory stimuli seem to be the mechanism underlying the development of functional ID and anaemia in patients with chronic inflammatory disease as psoriasis.
The aim of the study is to estimate the iron status (the level of iron, TIBC, sTfR) hepcidin and heme oxygenase 1 in order to declare the iron status in Egyptian psoriasis patients and investigate the role of heme oxygenase in the pathogenesis of psoriasis.
Our study included 101subjects, two groups: 51 patients with psoriasis vulgaris.They were males and females with ages ranged between 17 years and 75 years recruited from the out-patient clinic of Dermatology Department in Beni suef University Hospital .The disease duration ranged from 1week to 23 years.
A comparative control group of 50 subjects without psoriasis. They were males and females with ages ranged between 23 and 66 years (after matching with the cases).
We investigated biomarkers of iron status [iron, hepcidin, soluble transferrin receptors (sTfR) and total iron binding capacity (TIBC)].We also measured hepcidin level in plasma using ELISA test. We measured HO-1 expression using realtime PCR in cases and controls.
TGs and cholesterol and high density lipoprotein (HDL) were measured in cases and controls
It was found that iron, TIBC and hepcidin were significantly lower in cases compared to healthy controls. On the contrary, sTfRs were significantly higher in cases compared to healthy controls. The TIBC was only related to disease duration and hepcidin was related to weight and BMI of cases.
We found elevated expression of HO-1in cases when compared to controls. The expression of HO-1 tends to be higher in those with a smaller body surface area involved and lower disease activity (PASI score).
The TG and cholesterol mean level were significantly lower in controls compared to cases .The HDL mean level was significantly higher in cases compared to controls.
There was no statistically significant difference between both groups regarding age, BMI and sex.
The iron deficiency in psoriasis could be explained by the hyperproliferative nature of the disease that accelerates loss of nutrients from the hyperproliferation and desquamation of the epidermal layer of skin in psoriatic patients.
We can conclude that psoriasis is associated with deranged iron status demonstrated by iron deficiency, decreased TIBC, hepcidin and elevated sTfR levels in psoriasis patients compared to controls.
A strong overexpression of HO-1 means that HO-1 has a role in the pathogenesis of psoriasis and in skin inflammation..
Supplying the patients with psoriasis with iron is important to maintain haematopoiesis and the induction of HO-1 might have be a promising approach for the treatment of psoriasis through its antioxidant and immunomodulatory role.