الفهرس 
CadmiumOnly 14 pages are availabe for public view
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Abstract
Introduction: Cadmium (Cd) is one of the most toxic non-essential toxic metals, an environmental and occupational pollutant endangering human and animal health. Aim of the study: Due to carnosine’s multifunctional properties, the present study was designed to study the effect of carnosine as potential antioxidant agent on cadmium–induced lipid peroxidation and renal oxidative stress in aged rats. Materials and Methods: The present study was performed on 45 female Wistar rats, weighing at the start of the study between 280-380 g. During the experimental protocol the animals were maintained in the animal room at the physiology department with 12 hours periods of light and darkness under standard conditions of boarding with environmental temperature 20-25°C, and received food and tap water ad libitium. Animals were left for 10 days to acclimatize, housed in animal acrylic cages (45x38x18cm). Results: The results encountered in the present study reflect the changes in serum urea, creatinine, albumin, superoxide dismutase, malondialdehyde, nitric oxide, tumor necrosis factor-α and interleukin 10 levels, as well as blood and renal tissue cadmium levels, renal tissue superoxide dismutase, tumor necrosis factor-α and nitric oxide levels in control, cadmium, and carnosine treated groups. Summary and Conclusion: Due to carnosine’s multifunctional properties, the present study was designed to study the effect of carnosine as potential antioxidant agent on cadmium–induced renal oxidative stress and lipid peroxidation.