الفهرس 
Chapter (1): Polycystic ovary syndromeOnly 14 pages are availabe for public view
 |  | from | 158 |  |  |
| | | from | 158 | | |
Abstract
Background: The aim of the current study was to compare the efficacy of Letrozole and Clomiphene citrate, as a first line treatment for induction of ovulation in cases of polycystic ovary syndrome.
Methods: this study was randomized comparative study involving (80) Egyptian women were diagnosed as having Polycystic ovary syndrome attending Ain Shams University Maternity Hospital (Infertility out-patient clinic). During the initial visit, anthropometric measurements and baseline investigations were performed. Patients were randomized to 5.0 mg Letrozole daily (40 Patients) or 100 mg Clomiphene citrate (40 Patients) from the third until the eighth day of menstruation. Serial transvaginal scans were performed to see the dominant follicles, endometrial thickness and number of follicles. Transvaginal scans were performed serially to look for evidence of ovulation.
Results: The subjects were homogenously distributed. The difference between Letrozole and Clomiphene citrate for ovulation rate was 35 (87.5%) versus 24 (60%). Patients taking Letrozole exhibited a mean endometrial thickness (ET) at mid cycle of menses (Day 11-D14) of 9.2 mm (SD 2.37) versus 8.4 mm (SD 1.61) for patients taking Clomiphene citrate, and these differences were statistically significant (P < 0.0001). In terms of pregnancy rate, Letrozole facilitated pregnancy induction in 15 patients (37.5%) versus 6 patients (15%) for Clomiphene citrate, this was statistically significant (P = 0.02). More dominant follicles exhibiting a mono-follicular morphology were observed in patients treated with Letrozole compared to patients treated with Clomiphene citrate, with a mono-follicular dominant follicle observed in 18 (45%) versus 11 (27.5%) patients, respectively.
Conclusion: Letrozole provided a more efficient stimulation compared to Clomiphene citrate in terms of ovulation induction, thickening of the endometrial lining and achievement of a successful pregnancy.