الفهرس 
Risk Factors For IONVOnly 14 pages are availabe for public view
 |  | from | 93 |  |  |
| | | from | 93 | | |
Abstract
Background: Spinal anesthesia has been associated with intraoperative nausea and vomiting (IONV), especially during cesarean section, which is attributed to several mechanisms.
Objective: The purpose of this study is to compare effects of granisetrone, subhypnotic propofol and propofol and dexamethasone in combination on the occurrence and severity of intraoperaive and early postoperative nausea and vomiting in elective cesarean section under spinal anesthesia.
Methods: In a randomized, double-blind, and placebo-controlled clinical trial, 300 parturients, ASA class I and II, aged 18-35 years, who undergone spinal anesthesia for cesarean section were randomly allocated to one of three groups: group G (receiving Granistron 40 μg/ kg, n=100), group P (receiving propofol 20 mg bolus and 1 mg/kg/hr, n = 100), and group PD (receiving propofol 20 mg bolus plus 8 mg of dexamethasone followed by and 1 mg/kg/hr, n=100) intravenously (IV) immediately after umbilical cord clamping. Introperative and early postoperative emetic episodes, severity of emesis, scores of sedation and ephedrine consumption were recorded.
Results: The rate of emetic symptoms (nausea, retching, and vomiting) was lower in patients who received the combination antiemetic regimen and granisetron than in those who received subhypnotic-dose propofol 1.0 mg/kg per hour alone which is statistically significant (P ≤ 0.05). The severity of nausea was not statistically different between the groups.
Conclusion: Despite adequate control of risk factors for IONV, the use of an antiemetic is usually still needed. The combination of propofol and dexamethasone seemed to be as effective asgranisetron and both more effective than propofol alone.