الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
group II : included 29 patients with benign effusion (age and gender
matched) as a control group.
All subjects included in the study were subjected to the following:
Full history taking, Detailed general and local chest examination, Chest
radiograph, computed tomography (C.T), Bronchoscopy, Sputum
examination, Thoracocentesis, Laboratory investigations including:
Cytological examination of pleural fluid for malignant cells , Biochemical
analysis of pleural fluid for differentiation between exudates and
transudates according to Light`s criteria and Detection of cell free DNA
in pleural fluids by real time PCR .
Our results shows asignificant increase in group(1) compared to
group(2) regarding to DNA integrity index, while non significant
difference as regarding the Alu 115 and Alu 247 levels between the
studied groups.
Also, our results shows that: the diagnostic accuracy of DNA
integrity index in diagnosis of malignant pleural effusion is (1.2),with
sensitivity (94.9%), specificity (86.2%), positive predictive value(75.5%)
and negative predictive value(92.6%) at cutoff point of 0.8189
IU/ml.while, the diagnostic accuracy of combinations of DNA integrity
index and cytology in diagnosis of malignant pleural effusion is
(0.94),with sensitivity (100%), specificity (86%), positive predictive
value(0.91%) and negative predictive value(1.00%).
The performance levels of ALU 247, ALU115, DNA integrity
levels using ROC curve indicating the validity of ccfDNA to discriminate
malignant pleural effusion and benign ones.