الفهرس 
Nasal polyposisOnly 14 pages are availabe for public view
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Abstract
This is an interventional clinical trial demonstrating the effect of vitamin D deficiency in chronic rhinosinusitis with nasal polyposis.
Methodology: Fifty patients with the clinical diagnosis of chronic rhinosinusitis with nasal Polyposis (CRSwNP) at Otorhinolaryngology outpatient clinic, Ain Shams University hospitals. group I will be subdivided into 2 subgroups, group Ia: twenty five patients will receive vitamin D supplementation, while group Ib will receive local and systemic steroids.
Results: chronic rhinosinusitis with nasal polyps’ (CRSwNP) populations are vitamin D deficient, clinical improvement was noted in chronic rhinosinusitis with nasal polyps’ (CRSwNP) population both by history and examination (reduction in nasal polyp size, decrease in mucosal edema, change of secretion consistency) after vitamin D3 supplementation, ), but better response and improvement was demonstrated in the steroids treated group.
Conclusion: Vitamin D role in pathogenesis of CRSwNP is now just beginning to be better understood. While it remains unclear whether Vitamin D deficiency is causational in this disease, there is likely a role for its use as a disease-modifying, more specific agent (either alone or as a synergistic agent to traditional therapeutics) in treatment (or prophylaxis) of patients with recurrent or recalcitrant cases, or cases not candidate for surgery (either unfit or refusing).