الفهرس 
• Pulmonary hypertensionOnly 14 pages are availabe for public view
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Abstract
As pulmonary hypertension is a hemodynamic definition, rather than being a primary disease state, virtually all disorders that affect pulmonary vasculature may cause PH. Pulmonary arterial hypertension (PAH), which forms group 1 of the Venice classification, constitutes a group of disorders that are characterized by hypertrophic and thrombotic obstructive changes in the pulmonary arterial tree. Platelet abnormalities and abnormal platelet activation are important mediators of disease progression, as they both contribute to thrombotic obstruction of pulmonary arteries and induce vessel remodeling.In view of the above, the present study was undertaken to investigate platelet activation in different causes of pulmonary hypertension by means of mean platelet volume measurement.A total of 40 patients with different causes of pulmonary hypertension, and 20 controls were included in the study with age range from 25 to 68, all patients and controls’ past medical data, admission echocardiograms, PFT and complete blood counts were reviewed.The results obtained were collected, tabulated and submitted for statistical analysis.The following results were obtained: •Patients with pulmonary hypertension had higher mean platelet volume levels compared to healthy controls (P value 0.007) •Mean platelet volume did not correlate with right ventricular systolic pressure. •Platelet count was within normal range in patients with pulmonary hypertension. •It was found that there is no correlation between platelet count and the values of TR and RVSP in neither pulmonary hypertension nor control groups.•FVC was lower than normal in both COPDPH and MVDPH patients.