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العنوان
biochemical antitumor studies of some nitrogen heterocycles /
المؤلف
barbar, mai hesham ahmed.
هيئة الاعداد
باحث / مي هشام أحمد بدير
مشرف / إبراهيم السيد محي الدين
مشرف / لمياء عبد اللطيف علي بركات
مناقش / مني احمد صادق
مناقش / فاتن زهران محمد
الموضوع
antitumor studies. nitrogen heterocycles.
تاريخ النشر
2017.
عدد الصفحات
154 p. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
الكيمياء
تاريخ الإجازة
1/8/2017
مكان الإجازة
جامعة بورسعيد - كلية العلوم ببورسعيد - الكيمياء
الفهرس
Only 14 pages are availabe for public view

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from 186

Abstract

The development of prodrugs that are enzymatically activated into anticancer agents is a promising perspective in cancer therapy. Many nitrogen-containing quinoid heterocycles have been reported to show antitumor effect. The principal interest in these compounds lies on their potential to produce tumor-selective toxicity. selectivity occurs by difference in oxygen tension between normal and tumor tissue and by levels of the required activating enzymes. In this review a summary of the most interesting heterocyclic quinones is given together with their biological property. SAR studies concerning the importance of some structural features will be described.