الفهرس 
tiology, Pathophysiology and Epidemiology of MeningitisOnly 14 pages are availabe for public view
 |  | from | 152 |  |  |
| | | from | 152 | | |
Abstract
Meningitis is a disease caused by the inflammation of the protective membranes covering the brain and spinal cord known as the meninges. The inflammation is usually caused by an infection of the fluid surrounding the brain and spinal cord. (CDC, 2014). Bacterial meningitis is a life-threatening infection of the central nervous system. Mortality is approximately 20% in high-income countries despite available treatment with antibiotics and dexamethasone, and is several times higher in low-income countries. Glimåker et al., in a study over 712 patients found that the information about hearing disability or neurological deficits at follow-up 2–6 months after discharge was reported in 535 patients and in similar frequencies during the 2 study periods (85% in 2005–2009 and 81% in 2010–2012). The risk of sequelae was significantly associated with gender, age, etiology, and mental status on admission. This study aims to: Evaluation of the potential role of CSF lipocalin 2 in the differentiation between bacterial and aseptic meningitis in the setting of acute meningitis It is important to distinguish bacterial meningitis from aseptic meningitis during the acute phase of the disease, when clinical symptoms are often similar. This could help to avoid complication and to limit unnecessary antibiotic use and hospital admissions. Repeated CSF analysis should be performed for any patient who has not responded clinically after 48 hours of appropriate antimicrobial therapy. The aim of this present study is to test the reliability of CSF NGAL level in diagnosis and early differentiation between bacterial and aseptic meningitis. For this purpose, 70 patients were selected from total admission in Abbassia fever hospital with clinical presentation of acute meningitis, and CSF analysis suggestive of meningitis hospital between March 2016 and February 2017 with picture of meningitis. The following flowchart explain the classification of total number of patients admitted to Abbassia Fever Hospital during the study period.