الفهرس 
Pharmacology of SugammadexOnly 14 pages are availabe for public view
Abstract
Background: Adequate reversal of neuromuscular block is an important consideration in anaesthesia. Restoration of normal neuromuscular function may occur spontaneously or may be hastened with the use of acetylcholinesterase inhibitors such as neostigmine.
Aim of the work: The aim of this study is to assess the efficacy of sugammadex in reversal of deep neuromuscular blockade induced by steroidal muscle relaxant in surgical patients. We will use rocuronium & pancuronium. In addition, safety variables (particularly adverse event information) of sugammadex will be assessed. Patients and Methods: This randomized prospective study was carried out in Ain Shams University Hospitals after approval of Research Ethics Committee (REC) at Ain Shams University and written informed consent from 80 patients. Eligibility of patients in study includes age of 20-60 years, both sex, ASA physical status I–II, elective surgery requiring muscle relaxation, in a supine position, with an anticipated duration of about 1.5–3.0 hours.
Results and Conclusion: Sugammadex can rapidly and effectively reverse profound rocuronium- induced neuromuscular blockade, without apparent side effects. While sugammadex showed no significant effect on recovery of pancuronium induced deep block. Further studies with higher dose of sugammadex are needed to study reversal of deep pancuronium induced neuromuscular blockade by sugammadex.