الفهرس 
Introduction and Aim of the workOnly 14 pages are availabe for public view
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Abstract
Aim : This study investigate the protective effect of CIL and DPY on experimentally induced gastric ulcer by CRS in adult and aged rats.
Results: The results obtained in the present study showed that all rats exposed to CRS developed gastric lesions. Aged rat groups were more susceptible to peptic ulcer than adult one. Pre-treatment with CIL and DPY ameliorated the ulcer index and produced a potential protective effect in both adult and aged CRS induced rats compared to CRS model in adult and aged rats, respectively.
The gastric mucosal content of MDA was increased, while the concentrations of GSH and GPx were decreased in both adult and aged CRS induced rats compared to their control groups with more significant changes in aged CRS induced rats compared to adult CRS induced rats. The gastric mucosal NO, PGE2 concentrations and gastric juice content of mucin were reduced in both adult and aged CRS induced rats compared to their control groups with more significant decrease in aged CRS groups compared to adult CRS groups.
This study showed that pretreatment of CRS induced rats with CIL and DPY increased gastric mucosal NO, PGE2 concentrations and gastric juice content of mucin concentration in both adult and aged rats. A significant decrease in both COX-1 and COX-2 gastric mucosal protein expression in CRS induced adult and aged rats. This decrease was more significant in aged rats compared to adult rats. Pretreatment with CIL and DPY increased gastric mucosal expressions of both COX-1 and COX-2 in both adult and aged CRS induced rats compared to control CRS induced adult and aged rats, respectively.
A significant increased in gastric mucosal TNF-α protein expression in CRS in both adult and aged rats. This increase was more significant in aged CRS groups compared to adult CRS groups indicating that the aged gastric mucosa is exposed to more susceptible condition of inflammations than younger age. Pretreatment with CIL and DPY produced significant inhibition in the expression of TNF-α in both adult and aged rats, suggesting a possible anti-inflammatory role of CIL and DPY.
A significant increase in the gastric mucosal MPO activity in CRS in both adult and aged rats and this increase was significantly higher in aged rats compared to adult rats. Pretreatment of CRS adult and aged rats with CIL and DPY showed a significant decrease in the gastric mucosal MPO activity compared to control CRS-induced adult and aged rats, respectively, suggesting a possible anti-inflammatory role of CIL and DPY.