الفهرس | Only 14 pages are availabe for public view |
Abstract Platelet rich plasma (PRP) is a simple, low-cost, and minimally invasive method that allows a high concentrate of autologous growth factors in physiologic proportions to be obtained from blood, which can be easily and safely injected. Transforming growth factor-beta-1 (TGF-B1) induces a positive change in the articular environment, regulate angiogenesis, and induce the synthesis of hyaluronic acid in the synovial membrane. Intra-articular injection of autologous PRP has been increasingly implemented on patients with osteoarthritis. PRP reduces pain and improves function over time and currently seems to be considered as one of the treatment options for osteoarthritis. The aim of this study was to determine the efficacy of intra-articular injections of PRP in patients with Knee Osteoarthritis. This study was carried out on 35 patients suffering from primary knee osteoarthritis grade I, grade II and grade III. There were 24 female and 6 male patients. Their age range from 30 to 65 years with average 52 years, their body mass index (BMI) ranged from 22.2 to 54.11 kg/m2 with average 38 kg/m2, the period of complaint ranged from 3 to 108 months with average 25 months, the laterality was left (11 cases) and right (19 cases), grade was 2 cases grade I, 23 cases grade II and 5 cases grade III. All patients were treated by 2 intra-articular injection of PRP treatment, post injection follow up period was 1 year . The clinical results were classified on subjective base and were graded as Excellent in 19 patients (63.3 %), Good in 6 patients (20 %) and Poor in 5 patients (16.7 %). Platelets had significant effect on the results as it increased, activated and released growth factors which had role in osteoarthritis improvement. Age and Sex had no statistically significant effect on the results. Period of complaint had statistically no significant effect on results. Grade of osteoarthritis had statistically significant effect on results as the more degeneration of the joint the less viable cells the smaller potential for growth factors response. Body mass index (BMI) had statistically significant effect on results as the large weight cause cartilage degeneration. |