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العنوان
Investigation of drug crystalline structure modification as a tool for enhanced oral bioavailability /
المؤلف
Arafa, Mona Farouk Mahmoud.
هيئة الاعداد
باحث / منى فاروق محمود عرفة
مشرف / سناء عبدالغنى الجيزاوى
مشرف / جمال محمد المغربى
مشرف / محمد على عثمان
الموضوع
Pharmaceutical Technology.
تاريخ النشر
2017.
عدد الصفحات
p 296. :
اللغة
الإنجليزية
الدرجة
الدكتوراه
التخصص
العلوم الصيدلية
تاريخ الإجازة
12/9/2017
مكان الإجازة
جامعة طنطا - كلية الصيدلة - التكنولوجيا الصيدلية
الفهرس
Only 14 pages are availabe for public view

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Abstract

The dissolution rate of drugs is a determining factor for drug bioavailability after oral administration. This factor provides the main challenge in development and formulation of effective drug candidates. Now more than 40% of drugs in the development pipelines and about 60% of the drugs coming from synthesis suffer from low bioavailability after oral administration with poor drug dissolution being the main reason for this.Accordingly, scientists are probing many approaches to enhance drug dissolution rate. These include particle size reduction, microemulsification,micellar solubilization, co-solvency.