الفهرس | Only 14 pages are availabe for public view |
Abstract Borderline personality disorder (BPD) and major depressive disorder (MDD) have a high rate of co-morbidity, as will as they share sleep symptoms. More than 70% of individuals with BPD have a lifetime history of major depression. Conversely, co-morbid BPD has been diagnosed diagnosed in about 25% of individuals diagnosed with major depression or dysthymia. Both BPD and MDD patients complain of sleep disruptions; in BPD the prevalence of sleep related problems has been reported to range from 15% to 95.5%, while sleep disturbances are reported by 60 – 90% of patients with major depressive disorder (MDD). The aim of this study is to examine polysomnographic parameters in borderline personality disorder patients without MDD in comparison with MDD patients for better understanding of the nature of the depressive symptoms in BPD. As there is overlapping between both disorders concerning manifestations, especially, in affective symptoms and sleep problems, our study is a contribution to several attempts to answer the difficult question ”is there overlapping between BPD and MDD in the biological substrate or not?” The present study included three groups; group I included ten patients with borderline personality disorder according to DSM-5 diagnostic criteria. group II include ten patients with major depressive disorders according to DSM-5. group III included ten healthy persons as a control group. Concerning group I, four patients were recruited as inpatients from department of neuro-psychiatry in Tanta University hospital, and the remainder sex subjects were recruited from outpatient clinic. Concerning group II, four patients were recruited as inpatients from department of neuro-psychiatry in Alexandria University hospital, and two patient were recruited from outpatient clinic of department of neuro-psychiatry in Tanta University hospital. Polysomnographic study in borderline personality disorder patients; a comparison with major depressive disorder Summary 126 Inclusion criteria were any sex, age between 18 and 60 years old. All subjects are matched as regards age and sex. Exclusion criteria in all groups were age above 60 years old and below 18 years old, other current DSM-5 disorders, comorbid medical or neurological disorders, and comorbid substance abuse. All diagnoses were based on DSM-5 criteria. All 20 patients were assessed with the 24-item Hamilton Depression Rating Scale (HDRS), and were screened for substance abuse. Participants were instructed to arrive at the sleep laboratory t at 20:00 each night for electrode montage and preparation. The 20 patients undergo a psychotropic, antidepressant, and neurotropic drug washout period for double half-life before the sleep recordings. All participants were asked to refrain from excessive caffeine and nicotine before coming to the laboratory. Patients and controls spent two nights in the sleep laboratory. The first night served for adaptation to the laboratory procedures and environment. The first night served for adaptation to the laboratory procedures and environment. All subjects were evaluated in an accredited sleep laboratory in sound- attenuated rooms, monitored by an infrared camera. Nicolet sleep diagnostic system was used. PSG signals were digitized at a sampling rate of 512 Hz using a commercial software product (Nicolet One modular neurodiagnostic software system- nEEG module). A 12-channel montage was utilized to record the following: 1. EEG (C3-A2, C4-A1, O1-A2, O2-A1) 2. Horizontal and vertical eye movements. 3. Submental and leg electromyogram (left and right anterior tibial muscles). 4. Electrocardiogram. Polysomnographic study in borderline pers. |